Pub. Date : 1990 Dec 5
PMID : 2249989
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on expression of pulmonary surfactant proteins, SP-A and SP-B, were determined in a human pulmonary adenocarcinoma cell line (H441-4). | Tetradecanoylphorbol Acetate | surfactant protein B | Homo sapiens |
| 2 | Expression of a distinct surfactant protein, SP-B, was also markedly decreased after exposure to TPA. | Tetradecanoylphorbol Acetate | surfactant protein B | Homo sapiens |
| 3 | SP-A and SP-B mRNA contents decreased more rapidly after treatment with TPA than after actinomycin D. | Tetradecanoylphorbol Acetate | surfactant protein B | Homo sapiens |
| 4 | Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription. | Tetradecanoylphorbol Acetate | surfactant protein B | Homo sapiens |
| 5 | Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription. | Tetradecanoylphorbol Acetate | surfactant protein B | Homo sapiens |