Title : Vanadate augments insulin binding and prolongs insulin action in rat adipocytes.

Pub. Date : 1990 Dec

PMID : 2249624






1 Functional Relationships(s)
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1 We conclude that 1) low concentrations of vanadate (less than 200 microM) increase insulin receptor affinity and consequent insulin uptake in rat adipocytes; 2) the excess cell-associated insulin exists largely as intact hormone; and 3) the increased binding at low insulin concentrations results in an apparent increase in insulin sensitivity. Vanadates insulin receptor Rattus norvegicus