Pub. Date : 2012 Jun 1
PMID : 22493485
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. | Niacinamide | sirtuin 1 | Homo sapiens |
| 2 | Here, we present evidence to show that the effect of nicotinamide is mediated through an increase of the [NAD(+)]/[NADH] ratio and the activation of SIRT1, an NAD(+)-dependent deacetylase that plays a role in autophagy flux. | Niacinamide | sirtuin 1 | Homo sapiens |