Pub. Date : 2012 Jun
PMID : 22492524
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Biguanide/metal interactions are stabilized by extensive pi-electron delocalization and by investigating analogs of metformin; we provide evidence that this intrinsic property enables biguanides to regulate AMPK, glucose production, gluconeogenic gene expression, mitochondrial respiration, and mitochondrial copper binding. | Biguanides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Biguanide/metal interactions are stabilized by extensive pi-electron delocalization and by investigating analogs of metformin; we provide evidence that this intrinsic property enables biguanides to regulate AMPK, glucose production, gluconeogenic gene expression, mitochondrial respiration, and mitochondrial copper binding. | Biguanides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | In contrast, regulation of S6 phosphorylation is prevented only by direct modification of the metal-liganding groups of the biguanide structure, supporting recent data that AMPK and S6 phosphorylation are regulated independently by biguanides. | Biguanides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | In contrast, regulation of S6 phosphorylation is prevented only by direct modification of the metal-liganding groups of the biguanide structure, supporting recent data that AMPK and S6 phosphorylation are regulated independently by biguanides. | Biguanides | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |