Title : A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes.

Pub. Date : 2012 May 11

PMID : 22480687






3 Functional Relationships(s)
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1 Raloxifene stimulated a further increase in ERK1/2 phosphorylation in TNF-alpha-treated chondrocytes. Raloxifene Hydrochloride mitogen-activated protein kinase 3 Homo sapiens
2 In addition, the anti-apoptotic effects of raloxifene were completely abolished in ERK1/2 siRNA-treated chondrocytes. Raloxifene Hydrochloride mitogen-activated protein kinase 3 Homo sapiens
3 These results suggest that raloxifene prevents caspase-3-dependent apoptosis induced by TNF-alpha in human chondrocytes by activating estrogen receptors and the ERK1/2 signaling pathway. Raloxifene Hydrochloride mitogen-activated protein kinase 3 Homo sapiens