Title : New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.

Pub. Date : 2012 Apr 26

PMID : 22475216






1 Functional Relationships(s)
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1 In one series, C-3 hydroxyl derivatives were studied leading to a very active compound, when the C-3 hydroxyl group assumes 3beta stereochemistry (1, IC(50) = 0.18 muM). Hydroxyl Radical latexin Homo sapiens