Title : Oral coadministration of β-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation.

Pub. Date : 2012 Jul

PMID : 22473491






2 Functional Relationships(s)
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1 These pharmacokinetic data support the hypothesis that when the primary glucuronide is secreted into the duodenum via the bile duct, the glucuronide is converted by beta-glucuronidase back to the parent compound. Glucuronides glucuronidase, beta Rattus norvegicus
2 These pharmacokinetic data support the hypothesis that when the primary glucuronide is secreted into the duodenum via the bile duct, the glucuronide is converted by beta-glucuronidase back to the parent compound. Glucuronides glucuronidase, beta Rattus norvegicus