Pub. Date : 2012 Sep
PMID : 22471974
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flavocoxid is a novel flavonoid-based "dual inhibitor" of the COX and 5-LOX enzymes. | flavocoxid | lysyl oxidase | Homo sapiens |
| 2 | KEY RESULTS: Flavocoxid reduced prostate weight and hyperplasia, blunted inducible expression of COX-2 and 5-LOX as well as the increased production of PGE(2) and leukotriene B(4) (LTB(4) ), enhanced pro-apoptotic Bax and caspase-9 and decreased the anti-apoptotic Bcl-2 mRNA. | flavocoxid | lysyl oxidase | Homo sapiens |
| 3 | CONCLUSION AND IMPLICATIONS: Our results show that a "dual inhibitor" of the COX and 5-LOX enzymes, such as flavocoxid, might represent a rational approach to reduce BPH through modulation of eicosanoid production and a caspase-induced apoptotic mechanism. | flavocoxid | lysyl oxidase | Homo sapiens |