Title : Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.

Pub. Date : 2012 Jul

PMID : 22454534






4 Functional Relationships(s)
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1 Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB). Morphine cAMP responsive element binding protein 1 Mus musculus
2 Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB). Morphine cAMP responsive element binding protein 1 Mus musculus
3 Thus, we also analyzed morphine-dependent activation of CREB in F11 and NG108-15 cells. Morphine cAMP responsive element binding protein 1 Mus musculus
4 In contrast to the CREB stimulation found in NG108-15 cells, we observed an inhibitory effect of morphine in F11 cells, indicating cell type-specific regulation of CREB by morphine. Morphine cAMP responsive element binding protein 1 Mus musculus