Title : Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer.

Pub. Date : 2012 Jun

PMID : 22454149






1 Functional Relationships(s)
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1 Because CYP27B1 (1alpha-hydroxylase), the enzyme catalyzing 1,25(OH)(2)D(3) formation in the kidney, is also expressed in extrarenal tissues, we hypothesize that dietary vitamin D(3) will be converted to 25(OH)D(3) in the body and then to 1,25(OH)(2)D(3) locally in the cancer microenvironment in which it will exert autocrine/paracrine anticancer actions. Vitamin D cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus