Title : Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.

Pub. Date : 2012 Jun

PMID : 22452883






1 Functional Relationships(s)
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1 Moreover, such phospho-Smad1/5-mediated rapamycin responses were blocked by LDN-193189 (a BMPRI kinase inhibitor) or Noggin (a BMP antagonist) in LNCaP prostate cancer cells. LDN 193189 SMAD family member 1 Homo sapiens