Pub. Date : 2012 Jul
PMID : 22451700
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP1A2 inhibition by 667-coumarin was competitive, with a K(i) of 0.77 muM, a concentration exceeding by only 5-fold the maximal steady-state concentration of 667-coumarin in human plasma with the recommended dose of irosustat. | coumarin | latexin | Homo sapiens |
| 2 | 667-Coumarin also appeared to be a competitive inhibitor of CYP2C19 (K(i) = 5.8 muM) in human liver microsomes, and this inhibition increased with assessment in human hepatocytes. | coumarin | latexin | Homo sapiens |