Title : A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum.

Pub. Date : 2012 Sep

PMID : 22451348






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using this model, we assessed the effects of the inflammatory cytokine interleukin-1alpha (IL-1alpha), several bioactive sphingolipids and all-trans retinoic acid (RA) on ceramide levels in the SC. Ceramides interleukin 1 alpha Homo sapiens
2 Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels. Ceramides interleukin 1 alpha Homo sapiens
3 Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels. Ceramides interleukin 1 alpha Homo sapiens