Title : A physiologically based pharmacokinetic model of mitoxantrone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding.

Pub. Date : 2012 Jun

PMID : 22451016






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Since mitoxantrone is a substrate of the efflux transporters ABCG2 and ABCB1, the incorporation of efflux transporters may also be necessary to characterize the data obtained in low-dose studies. Mitoxantrone ATP binding cassette subfamily B member 1 Homo sapiens