Title : Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor.

Pub. Date : 1990 Nov 15

PMID : 2244911






2 Functional Relationships(s)
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1 Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM). 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine intercellular adhesion molecule 1 Homo sapiens
2 Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM). 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine intercellular adhesion molecule 1 Homo sapiens