Title : TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.

Pub. Date : 2012 May 11

PMID : 22447928






2 Functional Relationships(s)
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1 A cell-permeable decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 compared with the Pro Ala-substituted peptide. Proline FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
2 Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF6 interacts directly with activated SFKs to couple LPS engagement of TLR4 to SFK activation and loss of barrier integrity in HMVEC-Ls. Proline FYN proto-oncogene, Src family tyrosine kinase Homo sapiens