Pub. Date : 2012
PMID : 22442718
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 2 | Our previous finding that the muscle nicotinic acetylcholine receptor (nAChR) and the Na,K-ATPase interact as a regulatory complex to modulate Na,K-ATPase activity suggested that chronic, circulating nicotine may alter this interaction, with long-term changes in the membrane potential. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 3 | Our previous finding that the muscle nicotinic acetylcholine receptor (nAChR) and the Na,K-ATPase interact as a regulatory complex to modulate Na,K-ATPase activity suggested that chronic, circulating nicotine may alter this interaction, with long-term changes in the membrane potential. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 4 | Collectively, these results demonstrate that nicotine at chronic doses, acting through the nAChR-Na,K-ATPase complex, is able to modulate Na,K-ATPase activity in an isoform-specific manner and that the regulatory range includes both stimulation and inhibition of enzyme activity. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |