Title : Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.

Pub. Date : 2012 Mar 21

PMID : 22442066






1 Functional Relationships(s)
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1 Blocking NMDARs with memantine (30 mum) or GluN2B-containing receptors with ifenprodil (3 mum) prevents CREB shutoff effectively in CTX and MSNs, and also rescues both neuronal types from NMDA-mediated toxicity. Memantine cAMP responsive element binding protein 1 Rattus norvegicus