Title : Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death.

Pub. Date : 2012 Apr

PMID : 22436237






1 Functional Relationships(s)
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1 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. Reactive Oxygen Species interferon gamma Homo sapiens