Pub. Date : 2012 Jul
PMID : 22434044
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acute amphetamine administration activates glycogen synthase kinase-3 (GSK3) by reducing its inhibitory serine-phosphorylation in mouse striatum and cerebral cortex. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 2 | Acute amphetamine administration activates glycogen synthase kinase-3 (GSK3) by reducing its inhibitory serine-phosphorylation in mouse striatum and cerebral cortex. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 3 | Here we tested if regulation of Akt and GSK3 was similarly affected by longer-term administration of amphetamine, as well as of methylphenidate, since each of these is administered chronically in patients with attention deficit hyperactivity disorder (ADHD). | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 4 | After eight days of amphetamine or methylphenidate treatment, striatal Akt and GSK3 were dephosphorylated similar to reported changes after acute amphetamine treatment. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 5 | After eight days of amphetamine or methylphenidate treatment, striatal Akt and GSK3 were dephosphorylated similar to reported changes after acute amphetamine treatment. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 6 | Oppositely, in the cerebral cortex and hippocampus Akt and GSK3 phosphorylation increased after eight days of amphetamine or methylphenidate treatment. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 7 | These opposite brain region changes in Akt and GSK3 phosphorylation matched opposite changes in the association of Akt with beta-arrestin and GSK3, which after eight days of amphetamine treatment were increased in the striatum and decreased in the cerebral cortex. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 8 | These opposite brain region changes in Akt and GSK3 phosphorylation matched opposite changes in the association of Akt with beta-arrestin and GSK3, which after eight days of amphetamine treatment were increased in the striatum and decreased in the cerebral cortex. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |
| 9 | Thus, whereas the acute dephosphorylating effect of stimulants on Akt and GSK3 in the striatum was maintained, the response switched in the cerebral cortex after eight days of amphetamine or methylphenidate treatment to cause increased phosphorylation of Akt and GSK3. | Amphetamine | glycogen synthase kinase 3 beta | Mus musculus |