Pub. Date : 2012
PMID : 22428047
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. | Lactic Acid | solute carrier family 16 member 1 | Homo sapiens |
| 2 | In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. | Lactic Acid | solute carrier family 16 member 1 | Homo sapiens |
| 3 | In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. | Lactic Acid | solute carrier family 16 member 1 | Homo sapiens |
| 4 | Together with the previous demonstration of MCT1 being a key regulator of lactate exchange between tumor cells, the current study identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities. | Lactic Acid | solute carrier family 16 member 1 | Homo sapiens |