Pub. Date : 2012 Jun
PMID : 22426400
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway. | polyglutamine | COP9 signalosome subunit 5 | Homo sapiens |
| 2 | In this study, we report on a novel target of expanded polyglutamine stretches, the transcriptional coactivator Jun activation domain-binding protein 1 (Jab1), which shares DNA-sequence-specific transcription factor targets with CBP. | polyglutamine | COP9 signalosome subunit 5 | Homo sapiens |
| 3 | In this study, we report on a novel target of expanded polyglutamine stretches, the transcriptional coactivator Jun activation domain-binding protein 1 (Jab1), which shares DNA-sequence-specific transcription factor targets with CBP. | polyglutamine | COP9 signalosome subunit 5 | Homo sapiens |
| 4 | We found that Jab1 accumulates in aggregates when co-expressed with either expanded polyglutamine stretches or N-terminal fragments of mutant htt. | polyglutamine | COP9 signalosome subunit 5 | Homo sapiens |
| 5 | In addition, the coactivator function of Jab1 was suppressed both by aggregated expanded polyglutamine solely and by mutant htt. | polyglutamine | COP9 signalosome subunit 5 | Homo sapiens |