Pub. Date : 2012 May-Jun
PMID : 22425525
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 2 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 3 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 4 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 5 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 6 | CPO is also responsible for the acetylcholinesterase (AChE) inhibition associated with CPF exposures; CPF is converted by liver CYP450 enzymes to CPO, which binds to and inhibits AChE and other serine active-site esterases, lipases and proteases. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |
| 7 | Our previous study demonstrated wide-ranging effects of neonatal CPO exposure on gene expression in the brain and on brain AChE inhibition, and modulation of both of these effects by the PON1(Q192R) polymorphism. | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | acetylcholinesterase | Mus musculus |