Title : Stimulation of human interleukin 1 production and specific mRNA expression by microtubule-disrupting drugs.

Pub. Date : 1990 Dec

PMID : 2242502






2 Functional Relationships(s)
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1 On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells. Vinblastine interleukin 1 alpha Homo sapiens
2 On the contrary, microtubule disrupters such as colchicine, vinblastine, and vincristine dramatically potentiate (15- to 35-fold), in a dose-dependent fashion, cell-associated IL1 and to a lesser extent (2.5- to 7-fold) released IL1 in the myelomonocytic THP1 cell line and in adherent peripheral blood mononuclear cells. Vinblastine interleukin 1 alpha Homo sapiens