Title : Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

Pub. Date : 2012 Apr 13

PMID : 22424946






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Leucine leucyl-tRNA synthetase 1 Homo sapiens
2 Here we show that leucyl-tRNA synthetase (LRS) plays a critical role in amino acid-induced mTORC1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mTORC1 activation. Leucine leucyl-tRNA synthetase 1 Homo sapiens
3 Here we show that leucyl-tRNA synthetase (LRS) plays a critical role in amino acid-induced mTORC1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mTORC1 activation. Leucine leucyl-tRNA synthetase 1 Homo sapiens
4 Mutation of LRS amino acid residues important for leucine binding renders the mTORC1 pathway insensitive to intracellular levels of amino acids. Leucine leucyl-tRNA synthetase 1 Homo sapiens