Pub. Date : 2012 Apr 13
PMID : 22424946
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Here we show that leucyl-tRNA synthetase (LRS) plays a critical role in amino acid-induced mTORC1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Mutation of LRS amino acid residues important for leucine binding renders the mTORC1 pathway insensitive to intracellular levels of amino acids. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |