Title : Rescue of interleukin-1 activity by leucovorin following inhibition by methotrexate in a murine in vitro system.

Pub. Date : 1990 Nov

PMID : 2242072






2 Functional Relationships(s)
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1 In the present study, we showed that the inhibition of IL-1 activity in vitro by MTX is dependent on folate pathways since, after the addition of leucovorin, the inhibitory effect of MTX was abolished. Folic Acid interleukin 1 complex Mus musculus
2 They also point to the fact that some IL-1 activities may be dependent on intracellular folate pathways. Folic Acid interleukin 1 complex Mus musculus