Title : Chemical modification reveals involvement of tyrosine in ligand binding to dopamine D1 and D2 receptors.

Pub. Date : 1990

PMID : 2241996






2 Functional Relationships(s)
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1 The tyrosine-alkylating agents, p-nitrobenzenesulphonylfluoride (pNBSF) and tetranitromethane (TNM) caused a time-and dose-dependent loss of the binding of [3H]SCH-23390 and [3H]spiroperidol, ligands specific for dopamine D1 and D2 receptors, respectively. Tetranitromethane dopamine receptor D1 Bos taurus
2 The tyrosine-alkylating agents, p-nitrobenzenesulphonylfluoride (pNBSF) and tetranitromethane (TNM) caused a time-and dose-dependent loss of the binding of [3H]SCH-23390 and [3H]spiroperidol, ligands specific for dopamine D1 and D2 receptors, respectively. Tetranitromethane dopamine receptor D1 Bos taurus