Title : Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro.

Pub. Date : 2012 Jun

PMID : 22415932






1 Functional Relationships(s)
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1 The formation of 1"-hydroxymidazolam was studied in pooled human liver microsomes (HLM) and recombinant human CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) in the presence of efavirenz (0.5, 1, and 5 muM). 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 5 Homo sapiens