Pub. Date : 2012 Nov
PMID : 22415590
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1beta-stimulated colon cancer cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 2 | In the present study, the effect of IP6 on the expression of MMP and TIMP genes was evaluated in unstimulated and IL-1beta-stimulated colon cancer cell line Caco-2. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 3 | MATERIALS AND METHODS: Real-time QRT-PCR was used to validate the transcription level of selected MMP and TIMP genes in Caco-2 cells after treatment with 1 ng/ml of IL-1beta, 2.5 mM of IP6, and both for 6, 12, and 24 h. RESULTS: Stimulation of cells with IL-1beta only resulted in an overexpression of MMP and their TIMP mRNAs. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 4 | IP6 was also an efficient downregulator of MMP-1, MMP-9, and TIMP-2 genes transcription stimulated by IL-1beta in 6 h lasting culture. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 5 | After 12 h, IL-1beta-induced MMP-2 mRNA expression was significantly reduced by IP6. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 6 | IP6 (2.5 mM) influences constitutive expression of both MMP and TIMP genes and downregulates IL-1beta stimulated transcription of some of these genes. | Phytic Acid | interleukin 1 beta | Homo sapiens |