Title : ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors.

Pub. Date : 2012 Jun

PMID : 22415310






2 Functional Relationships(s)
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1 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate C-C motif chemokine ligand 2 Homo sapiens
2 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate C-C motif chemokine ligand 2 Homo sapiens