Title : 5-HT(1A) receptor and apoptosis contribute to interferon-α-induced "depressive-like" behavior in mice.

Pub. Date : 2012 Apr 18

PMID : 22414862






1 Functional Relationships(s)
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1 These changes could be blocked by the 5-HT(1A) receptor agonist 8-OH-DPAT (0.5 mg/kg, i.p., 30 min before IFN-alpha administration), but not by the standard antidepressant imipramine (10 mg/kg, i.p., 30 min before IFN-alpha administration) although both of them could ameliorate the depressive-like behavior of mice. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus