Title : Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism.

Pub. Date : 2012 Apr 15

PMID : 22410117






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism. rottlerin protein kinase C delta Homo sapiens
2 Rottlerin, a selective inhibitor of novel isoforms of protein kinase C delta (PKC delta), has been shown to exert multiple effects on cancer cells, including inhibition of cell proliferation and migration. rottlerin protein kinase C delta Homo sapiens
3 Rottlerin, a selective inhibitor of novel isoforms of protein kinase C delta (PKC delta), has been shown to exert multiple effects on cancer cells, including inhibition of cell proliferation and migration. rottlerin protein kinase C delta Homo sapiens
4 Although rottlerin is known to inhibit PKC delta, PKC delta siRNA and overexpression of dominant-negative (DN)-PKC delta did not affect rottlerin-mediated induction of NAG-1. rottlerin protein kinase C delta Homo sapiens
5 These results suggest that rottlerin induces NAG-1 upregulation via a PKC delta-independent pathway. rottlerin protein kinase C delta Homo sapiens