Title : Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation.

Pub. Date : 2012 May

PMID : 22409268






1 Functional Relationships(s)
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1 These observations correlated with a strong inhibition of FLT3-ITD and its downstream targets STAT5, AKT and ERK1/2 upon ponatinib incubation, as determined by Western blotting. ponatinib AKT serine/threonine kinase 1 Homo sapiens