Title : Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.

Pub. Date : 2012 Mar 30

PMID : 22405772






2 Functional Relationships(s)
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Protein Name
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1 Treatment of mouse macrophage RAW264.7 cells with 1mM ATP induced high mobility group box 1 (HMGB1) release and IL-1beta production via activation of P2X7 receptor. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 Knockdown of P2X4 receptor or removal of extracellular Ca(2+) suppressed ATP-induced release of both HMGB1 and IL-1beta. Adenosine Triphosphate interleukin 1 beta Mus musculus