Title : BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.

Pub. Date : 2012 Jun 1

PMID : 22388934






1 Functional Relationships(s)
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1 In both hypoxia and monocrotaline-induced PAH rat models, which display reduced levels of bmpr2 transcripts, this study further indicates that the TGFbeta-MAPK axis is activated in lungs following elevation of both expression and phosphorylation of the TAK1 protein. Monocrotaline transforming growth factor beta 1 Homo sapiens