Pub. Date : 2012 Apr
PMID : 22388075
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway. | Imatinib Mesylate | caspase 3 | Homo sapiens |
| 2 | Meanwhile, imatinib (1-8 mumol/L) activated caspase-3 and its downstream mammalian STE20-like kinase 1 (Mst1), and induced apoptosis of K562 cells. | Imatinib Mesylate | caspase 3 | Homo sapiens |
| 3 | The caspase-3 inhibitor Z-VAD (40 mumol/L) reduced imatinib-induced H2AX phosphorylation at Ser139 and Tyr142 and blocked imatinib-induced apoptosis of K562 cells. | Imatinib Mesylate | caspase 3 | Homo sapiens |
| 4 | The caspase-3 inhibitor Z-VAD (40 mumol/L) reduced imatinib-induced H2AX phosphorylation at Ser139 and Tyr142 and blocked imatinib-induced apoptosis of K562 cells. | Imatinib Mesylate | caspase 3 | Homo sapiens |
| 5 | CONCLUSION: The caspase-3/Mst1 pathway is required for H2AX C-terminal phosphorylation at Ser139 and Tyr142 and subsequent apoptosis in Bcr-Abl-positive K562 cells induced by imatinib. | Imatinib Mesylate | caspase 3 | Homo sapiens |