Title : Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers.

Pub. Date : 2012 Jul

PMID : 22387464






1 Functional Relationships(s)
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1 We therefore targeted the activity of epigenetic modulators and found that chemical inhibition of histone deacetylases by valproic acid or DNA methyltransferases by 5-aza-2"-deoxycytidine facilitated dTALE-mediated activation of the epigenetically silenced oct4 promoter in NSCs. Valproic Acid POU class 5 homeobox 1 Homo sapiens