Title : Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.

Pub. Date : 2012 Mar 2

PMID : 22385968






1 Functional Relationships(s)
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1 Here we show that regulation of dendritic development of newborn neurons by Disrupted-in-Schizophrenia 1 (DISC1) during adult hippocampal neurogenesis requires neurotransmitter GABA-induced, NKCC1-dependent depolarization through a convergence onto the AKT-mTOR pathway. gamma-Aminobutyric Acid thymoma viral proto-oncogene 1 Mus musculus