Title : 3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A.

Pub. Date : 2012 Apr

PMID : 22373544






2 Functional Relationships(s)
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1 We establish the membrane ions" contributions (sodium, potassium, calcium and iron) mediated by water to the antagonism of these drugs at the 5-HT1A receptor. Potassium 5-hydroxytryptamine receptor 1A Homo sapiens
2 Our results indicate that potassium, calcium and iron play a key role for the antagonistic activity of drugs at the 5-HT1A receptor. Potassium 5-hydroxytryptamine receptor 1A Homo sapiens