Title : Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.

Pub. Date : 2012 Mar 22

PMID : 22352809






2 Functional Relationships(s)
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1 A trinucleoside glutamate derivative containing AZT, FLT, and 3TC (34, EC(50) = 0.9-1.4 muM) exhibited higher anti-HIV activity than AZT and 3TC against cell-free virus. Zidovudine latexin Homo sapiens
2 The physical mixture containing FLT-succinate, AZT, 3TC, and glutamic acid exhibited 115-fold less activity against cell associated virus (EC(50) = 91.9 muM) when compared to 34 (EC(50) = 0.8 muM). Zidovudine latexin Homo sapiens