Title : NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pH(i) in the vascular wall.

Pub. Date : 2012 Apr 15

PMID : 22351634






3 Functional Relationships(s)
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1 Omission of CO(2)/HCO(3)(-) caused VSMCs and ECs to acidify substantially more in NHE1 knockout (0.3-0.6 pH-units) than wild-type (0.02-0.1 pH units) mice. Bicarbonates solute carrier family 9 (sodium/hydrogen exchanger), member 1 Mus musculus
2 Removing CO(2)/HCO(3)(-) inhibited acetylcholine-induced NO-mediated relaxations in arteries from NHE1 knockout but not wild-type mice. Bicarbonates solute carrier family 9 (sodium/hydrogen exchanger), member 1 Mus musculus
3 Under physiological conditions, CO(2)/HCO(3)(-)-dependent mechanisms mask the pH(i)-regulatory function of NHE1. Bicarbonates solute carrier family 9 (sodium/hydrogen exchanger), member 1 Mus musculus