Title : Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.

Pub. Date : 2012 Feb

PMID : 22350013






2 Functional Relationships(s)
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1 We observed that butyrate treatment induced localization of MCT1 in the plasma membrane as well as overexpression of MCT4 and its chaperone CD147. Butyrates solute carrier family 16 member 1 Homo sapiens
2 Our results thus indicate that butyrate pre-treatment potentiates the effect of 3-BP, most probably by increasing the rates of 3-BP transport through MCT1/4. Butyrates solute carrier family 16 member 1 Homo sapiens