Pub. Date : 2012 Sep
PMID : 22348531
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. | Melatonin | mitogen-activated protein kinase 1 | Homo sapiens |
2 | Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. | Melatonin | mitogen-activated protein kinase 1 | Homo sapiens |
3 | Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. | Melatonin | mitogen-activated protein kinase 1 | Homo sapiens |
4 | Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. | Melatonin | mitogen-activated protein kinase 1 | Homo sapiens |