Title : Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling.

Pub. Date : 2012 Sep

PMID : 22348531






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. Melatonin mitogen-activated protein kinase 1 Homo sapiens
2 Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. Melatonin mitogen-activated protein kinase 1 Homo sapiens
3 Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. Melatonin mitogen-activated protein kinase 1 Homo sapiens
4 Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. Melatonin mitogen-activated protein kinase 1 Homo sapiens