Title : Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling.

Pub. Date : 2012 Sep

PMID : 22348531






1 Functional Relationships(s)
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1 Treatment with melatonin markedly inhibited phosphorylation of ERK1/2, JNK, p38 MAPK, IkappaB-alpha, and c/EBPbeta, blocked binding of NF-kappaB and c/EBPbeta to promoters, and suppressed p300 histone acetyltransferase (HAT) activity and p300 HAT-mediated NF-kappaB acetylation. Melatonin mitogen-activated protein kinase 8 Homo sapiens