Title : A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility.

Pub. Date : 2012 May

PMID : 22345441






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The two prolines (P310 and P341 of Japanese fulminant hepatitis 1 [JFH-1]) contained in these motifs, as well as a conserved tryptophan in the spacer region, were required for CyPA binding, HCV replication, and CPI resistance. Proline peptidylprolyl isomerase A Homo sapiens
2 Together, these data provide a high-resolution mapping of proline residues important for CyPA binding and identify critical amino acids modulating HCV susceptibility to the clinical CPI Alisporivir. Proline peptidylprolyl isomerase A Homo sapiens