Title : Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1.

Pub. Date : 1990 Oct

PMID : 2233688






3 Functional Relationships(s)
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1 Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus
2 An exception to this trend was observed for rats of gestational day 22, which exhibited transiently increased constitutive levels of CYP2B1, CYP2B2, and CYP3A1 mRNAs, such that PB-induced levels were not elevated over those observed in untreated animals. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus
3 These results were in contrast to data obtained previously for PB-inducible CYP2B1 and CYP2B2 mRNAs, which were distributed homogeneously across the hepatic lobule except for cells in the immediate vicinity of the periportal tract. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus