Pub. Date : 2012 Aug
PMID : 22335196
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | The observed suppression of proliferation was accompanied by the melatonin-mediated inhibition of COX-2, p300, and NF-kappaB signaling. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Melatonin significantly inhibited COX-2 expression and prostaglandin E(2) (PGE2) production, abrogated p300 histone acetyltransferase activity and p300-mediated NF-kappaB acetylation, thereby blocking NF-kappaB binding and p300 recruitment to COX-2 promoter. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Melatonin significantly inhibited COX-2 expression and prostaglandin E(2) (PGE2) production, abrogated p300 histone acetyltransferase activity and p300-mediated NF-kappaB acetylation, thereby blocking NF-kappaB binding and p300 recruitment to COX-2 promoter. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Pretreatment with a COX-2- or p300-selective inhibitor abrogated the melatonin-induced inhibition of cell proliferation, whereas PGE2 treatment or COX-2 transfection reversed the inhibition by melatonin. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Pretreatment with a COX-2- or p300-selective inhibitor abrogated the melatonin-induced inhibition of cell proliferation, whereas PGE2 treatment or COX-2 transfection reversed the inhibition by melatonin. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | These results therefore indicate that melatonin inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-kappaB, and PI3K/Akt/signaling and activating the Apaf-1/caspase-dependent apoptotic pathway. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |