Title : Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures.

Pub. Date : 2012 Jun

PMID : 22331680






3 Functional Relationships(s)
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1 Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. Phenobarbital cytochrome P450 family 2 subfamily C member 19 Homo sapiens
2 It has been reported that PB metabolism was affected by cytochrome P450 (CYP)2C19 polymorphisms in adults requiring dose adjustment. Phenobarbital cytochrome P450 family 2 subfamily C member 19 Homo sapiens
3 AIM: This study aimed to evaluate the effects of CYP2C19 genetic polymorphisms on PB pharmacokinetics (PK) in neonates and infants with seizures. Phenobarbital cytochrome P450 family 2 subfamily C member 19 Homo sapiens