Pub. Date : 2012 Apr 15
PMID : 22330067
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury. | Epirubicin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | The epirubicin-induced cell injury and increase of caspase-3/7 activity were also attenuated by p38 mitogen-activated protein kinase (MAPK) inhibitors, SB203580 and PD169316. | Epirubicin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Moreover, epirubicin significantly enhanced the phosphorylation of p38 MAPK, and these effects were attenuated by GSH and NAC. | Epirubicin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | These results indicate that an activation of p38 MAPK by oxidative stress is involved in the epirubicin-induced endothelial cell injury. | Epirubicin | mitogen-activated protein kinase 14 | Homo sapiens |